Document 0561
 DOCN  M9480561
 TI    Human T lymphotropic virus type I associated myelopathy and myasthenia
       gravis: a possible association?
 DT    9410
 AU    Fukui T; Sugita K; Ichikawa H; Negishi A; Kasai H; Tsukagoshi H;
       Department of Neurology, Showa University School of Medicine,; Tokyo,
       Japan.
 SO    Eur Neurol. 1994;34(3):158-61. Unique Identifier : AIDSLINE MED/94307313
 AB    We report the first known patient with human T lymphotropic virus type I
       (HTLV-I) associated myelopathy (HAM) and myasthenia gravis (MG). A
       50-year-old woman developed fluctuating muscle weakness with easy
       fatigability, transient bilateral blepharoptosis and double vision.
       Spastic paraparesis complicated these symptoms. Neurological assessments
       and specific laboratory findings revealed that the patient had definite
       HAM and MG. By inference from decreasing serum anti-HTLV-I antibody
       titers after thymectomy, the presence of antigenicity for HTLV-I in the
       thymic reticular cells, and a high incidence of various coexistent
       autoimmune diseases in HAM or MG, we suggested the possibility that
       these two diseases were associated with each other and with HTLV-I
       infection.
 DE    Adult  Aged  Autoantibodies/ANALYSIS  Carrier State  Case Report  Female
       Human  HTLV-I/*IMMUNOLOGY  HTLV-I Antibodies/ANALYSIS  Male  Middle Age
       Myasthenia Gravis/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY/THERAPY  Paraparesis,
       Tropical Spastic/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY/  THERAPY
       Pyridostigmine Bromide/ADMINISTRATION & DOSAGE  Receptors,
       Cholinergic/IMMUNOLOGY  Thymectomy  Thymus Gland/PATHOLOGY  JOURNAL
       ARTICLE

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